1. The history of neuromyelitis optica
  2. HEPATITIS C - Library
  3. Multiple sclerosis
  4. Current concept of neuromyelitis optica (NMO) and NMO spectrum disorders.

Realizamos una mención especial sobre la enfermedad de Devic y el lupus y finalmente hacemos unas notas El Texto completo solo está disponible en PDF. enfermedad ahora conocida como neuromielitis óp- La neuromielitis óptica ( NMO) o enfermedad de Devic es un trastorno autoinmune. PDF | We present a case report about a young woman initially treated as having La enfermedad de Devic es un desorden desmielinizante que se presenta.

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Enfermedad Devic Pdf

Archivo PDF: Kb. Texto completo. RESUMEN. La neuromielitis óptica ( NMO) o enfermedad de Devic, es una enfermedad inflamatoria infrecuente del. Keywords: Neuromyelitis optica, Devic's syndrome, Devic's disease, Castells CE: La neurópticomielitis aguda (Enfermedad de Devic). vol.9 número2 Enfermedad celiaca refractaria: cuando la dieta sin gluten no sana Síndrome de Ramsay Hunt: Español (pdf) · Articulo en XML; Referencias del artículo; Como citar este artículo; SciELO Analytics Devic neuromyelitis optica.

We examine the case of a male who was healthy up to the age of 8 years, when symptoms of a left hemiparesis appeared with a subacute onset and which were associated to symptoms of intracranial hypertension. A brain CAT scan showed a hypodense lesion in the right temporoparietal region, and the hypothesis of a tumoural lesion astrocyte was suggested. Treatment was started with dexamethasone and furosemide, and a complete regression of the symptoms and a considerable decrease in the cerebral lesion were observed. The second case is that of a female adolescent who, at the age of 11, developed a clinical picture of subacute onset of left hemiplegia. A brain CAT scan revealed hypodense lesions with ring-shaped contrast enhancement. In view of the histological diagnosis of an astrocyte, radiotherapy and corticotherapy are started. Both children presented recurrence of the lesions three years and nine months, in the first and second case respectively, after the first episode. Treatment with corticoid therapy was started and gave good clinical and radiological responses. It thus becomes possible to avoid invasive forms of treatment, such as surgical resection, which entail a number of sequelae.

Neuromyelitis optica: a new perspective.

The history of neuromyelitis optica

Semin Neurol. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med. A serum autoanti-body marker of neuromyelitis optica: distinction from multiple sclerosis. Neuromyelitis optica spectrum disorders.


Curr Neurol Neurosci Rep. A six years follow-up.

Journal of the Neurological Sciences. Mult Scler Int.

Multiple sclerosis

Magnetic resonance imaging of the brain and spine may show areas of demyelination lesions or plaques. Gadolinium can be administered intravenously as a contrast agent to highlight active plaques and, by elimination, demonstrate the existence of historical lesions not associated with symptoms at the moment of the evaluation.

These brain responses can be examined using visual - and sensory- evoked potentials. Phenotypes use the past course of the disease in an attempt to predict the future course.

They are important not only for prognosis but also for treatment decisions. In CIS, a person has an attack suggestive of demyelination, but does not fulfill the criteria for multiple sclerosis.

It is similar to the age that secondary progressive usually begins in relapsing-remitting MS, around 40 years of age. There is debate on whether they are MS variants or different diseases. The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability. Starting medications is generally recommended in people after the first attack when more than two lesions are seen on MRI.

Alternative treatments are pursued by some people, despite the shortage of supporting evidence.

Current concept of neuromyelitis optica (NMO) and NMO spectrum disorders.

The hygiene hypothesis proposes that exposure to certain infectious agents early in life is protective, the disease is a response to a late encounter with such agents. Only in a few cases and after many years does it cause demyelination.

Individuals having never been infected by the Epstein—Barr virus are at a reduced risk of getting MS, whereas those infected as young adults are at a greater risk than those having had it at a younger age. This has led to the theory that uric acid is protective, although its exact importance remains unknown.

These features interact in a complex and not yet fully understood manner to produce the breakdown of nerve tissue and in turn the signs and symptoms of the disease. These lesions most commonly affect the white matter in the optic nerve , brain stem , basal ganglia , and spinal cord , or white matter tracts close to the lateral ventricles.

The peripheral nervous system is rarely involved. When the myelin is lost, a neuron can no longer effectively conduct electrical signals.


Fitting with an immunological explanation, the inflammatory process is caused by T cells , a kind of lymphocyte that plays an important role in the body's defenses. The T cells recognize myelin as foreign and attack it, explaining why these cells are also called "autoreactive lymphocytes".

A further breakdown of the blood-brain barrier, in turn, causes a number of other damaging effects such as swelling , activation of macrophages , and more activation of cytokines and other destructive proteins.